Tripeptide that imitates the human body's own mechanism to produce collagen


Boosts and protects collagen to iron out wrinkles

INCI name: 

Palmitoyl Tripeptide-5


  • DSM

For fine lines and wrinkles.

SYN®-COLL is a patented synthetic peptide (Palmitoyl Tripeptide-5) that increases collagen levels by boosting both the collagen production AND the protection against degradation. Collagen-1 is boosted by the stimulation of TGF- Beta, and collagen is protected against stress-related formation of cytokines and enzymes. The in-vitro tests are supported by an in-vivo panel study that shows SYN®-COLL has excellent skin-smoothing and anti-wrinkle activity.

  • Boosts collagen and protects it from degradation
  • Safe alternative to collagen injection
  • Clinically tested and proven (in-vitro & in-vivo)
  • Easy to formulate
  • Stimulates hyaluronic acid synthesis in aged fibroblasts.


It is supplied as a PEG-free and preservative-free aqueous solution and is easy to formulate into most cosmetic bases.

New in-vivo data for ethnic (Chinese) skin is available in the presentation to download.

For a more detailed explanation of DSM's SYN® Peptide technology please click here.