Metabiotics™ Resveratrol is a new anti-ageing active manufactured using biofermentation with Pichia pastoris. The proprietary growth conditions allow the yeast to utilize the small molecule, resveratrol, during growth. During feeding, the cells are actively replicating, allowing utilization of the small molecule. Pichia pastoris utilizes resveratrol as a nutrient and by metabolization, the yeast convert the resveratrol into more bioavailable intermediates. Upon completion of the fermentation process, the yeast cells are then lysed and the extract is isolated.
There are changes in the peptide chemistry of the ferment due to the resveratrol treatment. The resveratrol also resulted in the increased expression of 96 unique proteins not seen in the untreated yeast. This demonstrates that Pichia pastoris has metabolized new proteins due to the treatment with resveratrol.
In vitro studies confirm that Metabiotics™ Resveratrol inhibits the activity of COX1, cyclooxygenase 1, a key pro-inflammatory mediator, and also promotes the synthesis of Type IV Collagen, COL4AI, superior to a resveratrol control.
The in vivo panel study with Metabiotics™ Resveratrol showed significant improvement in the overall appearance of the skin. Dramatic lifting was noted in the perioral area including smoothing of expression lines and ameliorating wrinkles. Improvement in the overall skin tone and texture was observed in all panelists.